SORBONNE UNIVERSITE (SU): Laboratoire Jean Perrin (LJP) at University Pierre et Marie Curie
EXPERTISE: The SU group will take care of the in vitro biofilm-related studies. Based on its expertise in real time monitoring of living biofilms. SU will contribute to establish biofilm action spectrum under evolving conditions and evaluate the in vitro efficiency of L-4-L products and strategies along the different steps of the project developments.
SU University Pierre et Marie Curie embodies excellence in science and medicine and has a clear commitment to the European community. European partnerships make up 64 percent of its institutional agreements, carried out with a three-pronged approach: European networks, education and research programmes.
LJP is one of the 100 research units at SU and specializes in physics at the interface with biology and medicine, investigating, for example, new physio-chemical and mechanical systems that could mimic biological systems and developing new experimental approaches in optics and microfabrication techniques that allow us to probe the properties of complex biological systems on different scales.
The LJP Micro-Organisms Biophysics group will provide the Light4Lungs project with equipment for biofilm growth in parallelized millifluidic channels and real-time monitoring using video microscopy with access to microfabrication facilities for dedicated growth chambers and an automated microscopy platform that allows real-time monitoring of living biological samples over long periods of time.
Nelly Henry, Senior Researcher at CNRS, has solid experience in physics and biology research. With a background in physico-chemistry, she has expertise in colloidal interactions in biological systems and has collaborated with immunologists (Curie Institute, C. Hivroz group) and microbiologists (JM. Ghigo’s group at the Pasteur Institute). She is also part of a group working on Nesseria meningitidis to better understand the mechanisms of bacterial self-aggregation (G. Duménil at HEGP). She recently launched a group at LJP to study adherent microbes and started work with INRA Micalis on multispecies biofilm. Nelly has coordinated several ACI and ANR programmes and has published papers in her field and work in major journals.
Jerome Robert is Assistant Professor at UPMC Paris 6 and conducts research at LJP. His recent research has focused on cell-to-cell heterogeneity in monoclonal bacterial populations. To study this phenotypic variability, he developed a microfluidic flow cytometer (combining a microfluidic chip and a microscope-based optical setup), which he used to measure fluorescence intensity on populations of bacteria. He is experienced in molecular biology, microfluidics and optical setups (microscopy and imaging). Jerome has also participated in and is currently a member of various university committees, including the Physics recruitment committee and the General Affairs committee at the Physics Department.