Light4Lungs

Light4Lungs addresses the problem of antimicrobial resistance in the treatment of chronic lung infections, the leading cause of morbidity and mortality in patients with diseases such as cystic fibrosis and hospital-acquired lung infections. The project aims to develop an alternative therapeutic scheme for the treatment of these infections: a novel inhalable photodynamic therapy.

Light4Lungs departs from current paradigms as bacterial infections will be treated by a breathable light source, thus:
(1) Without including any externally added drug it overcomes the multidrug resistance profile;
(2) With eliciting the therapeutic action by a breathable light source it avoids the use of invasive physical tethers.

The encompasses the development of particles with persistent luminescence, the aerosol technology for activation and delivery to the lungs, and the definition of the treatment parameters through toxicity and efficacy tests in clinically relevant models of respiratory infections. Its results have the potential to go beyond treatment of recalcitrant respiratory tract bacterial infections to other lung diseases and to other organs, enriching fields of healthcare, nanomedicine, materials science and nanotechnology.

Project objectives

In its four years of implementation Light4Lungs will work on:

Approach

The Consortium, with 8 partners from 4 countries, is highly interdisciplinary and synergetic, combining several different scientific areas from photonics to medicine, including materials chemistry, physical chemistry, photo-physics, pharmaceutics, photobiology and microbiology. Multidisciplinary teams will be assemble to ensure cross-talk between disciplines and specialists throughout the project.

Facts in brief

Funding organization EC / H2020 – FET Open
Timeframe December 2019 – November 2023
Funding amount 3,493,625.00 €
Coordinator INSTITUT QUIMIC DE SARRIA (IQS-URL)

Partners

INSTITUT QUIMIC
DE SARRIA

UNIVERSITA DEGLI STUDI
DI FIRENZE

SORBONNE UNIVERSITE
 

FUNDACIO PRIVADA
INSTITUT CATALA

UNIVERSITA DEGLI STUDI
DI PADOVA

CARDIFF SCINTIGRAPHICS LIMITED

THE UNIVERSITY
OF LIVERPOOL

WEDO PROJECT INTELLIGENCE
MADE EASY SL

Last News

Barcelona consortium meeting

Barcelona consortium meeting

On Monday, November 7th, and Tuesday, November 8th, we held our latest consortium meeting at the Ohla Eixample Hotel in Barcelona. The purpose of this meeting was to prepare for the report and the activities of each WP for the upcoming 6 months, which was addressed by...

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Light4Lungs Job Offer

Light4Lungs Job Offer

The Light4Lungs project is calling for applicants to a two-year post-doctoral position now open at research labs based in Paris. This opportunity to join the Light4Lungs research team will entail studying the interaction of light with bacterial biofilm with the aim of...

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Light4Lungs Project Review

Light4Lungs Project Review

As is customary one year in, the Light4Lungs project was reviewed on 27 January. This was an opportunity to take a look at the progress made over the previous twelve months and check that the project is on track to meet its milestones. The EU-funded Light4Lungs...

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